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nanomake L™ is India’s first automated microfluidic platform for precise and reproducible nano-formulation at the lab scale.
nanomake L™ utilizes both, single-use and multi-use microfluidic chips to enable reproducible scale-up of nano formulations, such as mRNA-lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes and emulsions while preserving their critical quality attributes. The instrument is based on controlled microfluidic mixing technology, ensures the production of uniform and reproducible high-quality nanoparticles.
Key Differentiators of nanomake - L™
Cost-Effective and Locally Manufactured
nanomake-L™ costs 40-60% less than imported microfluidic systems. Further, it incurs lower maintenance costs due to locally available components and technical support.Fully Automated & Plug-and-Play
Unlike conventional manual or semi-automated systems, nanomake-L™ operates with zero manual intervention, automating critical parameters such as priming, in-line dilution, flow rate, and mixing ratios.Multi-Use Microfluidic Chips
Unlike single-use systems, nanomake-L™ offers reusable, customizable microfluidic chips with different internal volumes and Material of Construction (MOC) options, making it adaptable for various applications.
Patented Microchannel Design
Our proprietary architecture enhances precision, ensuring uniform nano-formulation, critical for drug development and deliveryBroad Flow Rate Compatibility
Operates at 100 μL/min to 50 mL/min, enabling lab-scale and scale-up studies.Integrated Wash Program
The system includes an in-built cleaning mechanism, ensuring chip reusability while reducing cross-contamination and lowering operational costs.Scalability & Flexibility
Supports multiple syringe sizes (500 μL – 10 mL) and allows for the use of multiple nanomaterials for synthesis of lipid nanoparticles (LNPs), polymeric nanoparticles, and emulsions.
Why nanomake - L
User Friendly
Easy workflow, Automated operation build your templates.
Reproducibility
No batch-to-batch variations.
Nano formulation optimization in small volume
Formulation optimization using low volumes conserves expensive chemicals and minimizes waste.
Flexible operation
Wide range of process parameters like flow rate, flow rate ratio, in-line dilution on the same platform.
Multiuse Microfluidic Chip
Greener, low wastage.
Features
- Fully automated operation
- Multi-use microfluidic chip
- Wide range of flow rates on single platform
- Configurable 3 precursor pumps
- Built in washing program
- Interchangeable microfluidic chips
- Easily replaceable 2mL, 15mL and 50 mL sample collection attachments
Specifications
- Flow rates: 100 μL/min to 50 mL/min
- Temperature: Ambient to 60°C (optional pre-heater)
- No. of pumps (precursor): 3
- Syringe sizes: 500 μL, 1, 2.5, 5, 10 mL
- Microreactor: Multi-use microreactor
- Nanomaterial synthesis: Lipid, Polymer, Emulsions
- Controls: Total flow rate, flow ratio, sample volume, in-line dilution