nanomake L™ is a user-friendly microfluidic platform designed for rapid optimization and formulation of nanomedicines. This fully automated system, utilizes both, single-use and multi-use microfluidic chips to enable reproducible scale-up of nano formulations, such as mRNA-lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes, etc while preserving their critical quality attributes. This instrument, based on controlled microfluidic mixing technology, ensures the production of uniform and reproducible high-quality nanoparticles. With an option to work with a wide range of flow rates o`n a single platform and using three configurable precursor pumps for a precise process control, Nanomake L™ ensures efficient and versatile formulation of a range of nanoparticles. Its built-in washing program keeps the microchips clean, while the system’s versatility to accommodate microfluidic chips with different internal volumes, enhances the process flexibility and adaptability.